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发表于 2007-1-10 13:14:04
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re:这里一篇新文章讲到Porphyrins...
这里一篇新文章讲到Porphyrins 与自闭症的关系，引起很大关注。特别转贴在这里。文章主旨是：与正常孩子比，自闭症孩子体内有高水平的Porphyrins,这些Porphyrins的代谢物与大脑中的受体结合，导致自闭症。自闭症孩子体内有高水平Porphyrins,是因为重金属阻断了Porphyrins的代谢途经，导致Porphyrins升高。通过排出重金属，可以降低Porphyrins的水平，治疗自闭症。
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Heavy metals may be implicated in autism
27 May 2006
From New Scientist
URINE samples from hundreds of French children have yielded evidence for a link between autism and exposure to heavy metals. If validated, the findings might mean some cases of autism could be treated with drugs that purge the body of heavy metals.
Samples from children with autism contained abnormally high levels of a family of proteins called porphyrins, which are precursors in the production of haem, the oxygen-carrying component in haemoglobin. Heavy metals block haem production, causing porphyrins to accumulate in urine. Concentrations of one molecule, coproporphyrin, were 2.6 times as high in urine from children with autism as in controls.
Autism is thought to have a number of unknown genetic and environmental causes. Richard Lathe of Pieta Research in Edinburgh, UK, says he has found one of these factors. "It's highly likely that heavy metals are responsible for childhood autistic disorder in a majority of cases," he claims. The study will appear in Toxicology and Applied Pharmacology.
Lathe says these porphyrin metabolites bind to receptors in the brain and have been linked with epilepsy and autism.
The researchers restored porphyrin concentrations to normal in 12 children by treating them with "chelation" drugs that mop up heavy metals and are then excreted. It is not yet known whether the children's symptoms have eased, but Lathe cites anecdotal reports suggesting the drugs might do some good.
From issue 2553 of New Scientist magazine, 27 May 2006, page 21
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