[下载]DMG的作用：双盲试验

niuniu2007

３７个自闭孩子，３－１１岁，一组接受DMG,一组接受安慰剂。４周。

结果： 两组孩子都有一定的提高（行为标准）。两组的提高没有统计区别。孩子对DMG的反映不均一。一些吃了DMG的孩子似乎有好的变化，更少的一些孩子吃了DMG有坏变化，但总的来说和安慰剂组没有量上的(quantitative)差别。

没有原文（长篇的），所以不知道这里的行为测的是什么。我看有的报道有的孩子吃了DMG可以引起的多动或睡眠差的问题。

J Child Neurol. 2001 Mar;16(3):169-73. Links

Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.
Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M.
Department of Human Development, University of Texas at Dallas, USA. jkern1@mednet.swmed.edu

N,N-dimethylglycine, a dietary supplement, has been reported to be beneficial in children with autism and pervasive developmental disorder. We examined the effectiveness of dimethylglycine in children with autism and pervasive developmental disorder in a double-blind, placebo-controlled study. Thirty-seven children between 3 and 11 years of age with a diagnosis of autism and/or pervasive developmental disorder were gender and age matched and randomly assigned to receive either placebo or dimethylglycine for 4 weeks. All children were assessed before and after treatment on two behavioral measures, the Vineland Maladaptive Behavior Domain and the Aberrant Behavior Checklist. Standardized neurologic examinations before and after treatment on 33 children showed no change. An overall improvement on all behavioral measures was observed for both the placebo and the dimethylglycine groups. However, the improvement among the children who received dimethylglycine was not statistically different from the improvement observed among the children who received the placebo. The children who participated in this study were a heterogeneous group, and their apparent responses to the dimethylglycine varied. Some children appeared to respond positively to the dimethylglycine, and there was a smaller proportion of negative changes in the dimethylglycine group, but the quantitative changes in the dimethylglycine behavioral assessments were not significantly different from what was observed among children who received placebo.

niuniu2007

说实在的，37人的clinical trial也太小了，也只能写写学术文章，没有什么真正的临床意义。我只是偶然看到,我想有小批数据总比没有好吧。

好在DMG被认为是“食品”，较安全，但是说白了，水喝多了还中毒呢，所以也有剂量的问题。

就算是被批准的药，也有一个指标， 一般医生也不会和病人说，大概就是要有多少人吃，才会有一个人见效的意思。所以“合法”的药也不是人人都能见效的。

前一阵子看了ADHD的书，照说ADHD已经有很多药物了，但都是治标不治本，所以，家长们还是想找到治本的方法，所以neurofeedback很受推崇,也有排毒，饮食疗法，控制过敏，控制病毒酵母菌，真是似曾相识啊。