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自闭症研究进展

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1#
发表于 2008-11-25 14:34:54 | 只看该作者 回帖奖励 |正序浏览 |阅读模式
这个题目有点大,呵呵,最近有个热心的美国朋友帮我搜集了一些资料,有兴趣的可以看看,像秋爸爸这样的遗传专家可能早就了解了这些信息,要是哪天治疗自闭像治疗感冒一样简单就好了!

          
[/ALIGN]Autism                November 2008

Useful websites:
Autism Society of America: http://www.autism-society.org
Vitamin D council: http://vitamindcouncil.org/health/autism/
National Institute of Neurological Disorders: http://www.ninds.nih.gov/disorders/autism/detail_autism.htm

Summary

1. Cause
As we discussed, there is reasonable evidence for both genetic and environmental contributions to autism. For example, older parents, in particular fathers, but including mothers, have an increased risk of an affected child. Parents of affected children may also have an unusual behavior in that they more frequently watch the mouth of speakers more than the eyes, similar to autistic children. There is also an association with a mutation in Interleukin-1 Receptor Accessory Protein-Like 1 (IL1RAPL1), a gene implicated in calcium regulated vesicle release and dendrite differentiation. There appears to be no strong link to environmental factors as a cause. One report found an association with mercury intoxication, oxidative stress and increased risk of autism. Thimerosal, a mercury containing preservative in vaccines, has also been implicated in axon growth perturbation, suggesting that mercury might have a causal role in some cases. The 4:1 male:female ratio suggests that in utero exposure to testosterone might have a causal role.

2. Biomarkers
·        Increased mercury intoxication-associated urinary porphyrins (pentacarboxyporphyrin, precoproporphyrin, and coproporphyrin)
·        Lower levels of Levels of sP-selectin and sL-selectin
·        Mutations in Fibroblast Growth Factors (FGF) genes
·        Reduced GABA(A) receptors in three brain regions

3. Pharmacotherapy
Evidence for a positive effect is strongest for psychostimulants, noradrenergic reuptake inhibitors, antipsychotics, and alpha adrenergic agonists. Evidence for efficacy seems weakest for newer antidepressants, anxiolytics, and mood stabilizers. The antipsychotic risperidone is the only medication approved by the US Food and Drug Administration for irritability in autism. There is some suggestion that vitamin D may be involved in the cause and may be helpful (see website above on vitamin D).
Note that I did not review behavioral approaches to treatment because your child is already participating in one but can do so if you wish.

4. Effect on parents
Greater levels of daily positive mood were associated with more emotional and instrumental support, and less parenting stress and unsupportive interactions. Greater daily negative mood was associated with less emotional support and more parenting stress, unsupportive interactions, and disruptive child behaviors.


Cause
            Hum Mol Genet. 2008 Sep 18. [Epub ahead of print]   Links
Mutations in the calcium-related gene IL1RAPL1 are associated with autism.
Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team, Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA.
Centre for Excellence in Neuromics, CHUM Research Center and Department of Medicine, University of Montreal, Montreal, QC, H2L 4M1, Canada.
In a systematic sequencing screen of synaptic genes on the X chromosome, we have identified an autistic female without mental retardation who carries a de novo frameshift Ile367SerfsX6 mutation in Interleukin-1 Receptor Accessory Protein-Like 1 (IL1RAPL1), a gene implicated in calcium regulated vesicle release and dendrite differentiation. We showed that the function of the resulting truncated IL1RAPL1 protein is severely altered in hippocampal neurons, by measuring its effect on neurite outgrowth activity. We also sequenced the coding region of the close related member IL1RAPL2 and of NCS-1/FREQ, which physically interacts with IL1RAPL1, in a cohort of subjects with autism. The screening failed to identify nonsynonymous variant in IL1RAPL2 whereas a rare missense (R102Q) in NCS-1/FREQ was identified in one autistic patient. Furthermore, we identified by comparative genomic hybridization a large intragenic deletion of exons 3 to 7 of IL1RAPL1 in three brothers with autism and/or mental retardation. This deletion causes a frameshift and the introduction of a premature stop codon, Ala28GlufsX15, at the very beginning of the protein. All together, our results indicate that mutations in IL1RAPL1 cause a spectrum of neurological impairments ranging from mental retardation to high functioning autism.
PMID: 18801879 [PubMed

            Metabolism. 2008 Oct;57 Suppl 2:S40-3.   Links
Autism, a brain developmental disorder: some new pathopysiologic and genetics findings.
Costa e Silva JA.
University of Rio de Janeiro Medical School, 22461 Rio de Janeiro, Brazil. jacs@vetor.com.br
Autism is a severe neurodevelopmental disorder that is typically diagnosed by 3 years of age. Core symptoms of autism include profound deficits in social interaction and communication, restricted interests, stereotyped responses, and other repetitive patterns of behavior. Other abnormalities include mental retardation and comorbid epilepsy. These symptoms underscore the consequences of genetic inheritance for brain function and behavior. The etiology of autism may involve an interaction between genetic susceptibility (mediated by multiple genes) and environmental factors influencing brain development.
PMID: 18803965 [PubMed - inde
            Curr Biol. 2008 Sep 9;18(17):R748-R750.   Links

Autism: face-processing clues to inheritance.
Pellicano E.
Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK. liz.pellicano@bristol.ac.uk
When reading faces, autistic individuals gain considerably less information from the eyes and more from the mouth. A new study reports that some parents of autistic children use strikingly similar strategies, providing a crucial clue as to what might be inherited in autism.
PMID: 18786377 [

            Am J Epidemiol. 2008 Oct 21. [Epub ahead of print]   Links
Advanced Parental Age and the Risk of Autism Spectrum Disorder.
Durkin MS, Maenner MJ, Newschaffer CJ, Lee LC, Cunniff CM, Daniels JL, Kirby RS, Leavitt L, Miller L, Zahorodny W, Schieve LA.
This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age >/=35 vs. 25-29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age >/=40 years vs. 25-29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20-34 years and fathers aged <40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology
             Br J Psychiatry. 2008 Oct;193(4):316-21.   Links
Paternal age at birth and high-functioning autistic-spectrum disorder in offspring.
Tsuchiya KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S, Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
Osaka Hamamatsu Joint Research Center for Child Mental Development (OHJRC-CMD), Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
BACKGROUND: Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability. AIMS: To test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability). METHOD: A case-control study was conducted in Japan. The participants consisted of individuals with full-scale IQ>or=70, with a DSM-IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order. RESULTS: Eighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates. CONCLUSIONS: Advanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.
PMID: 18827294 [PubMed -
            J Neurol Sci. 2008 Sep 24. [Epub ahead of print]   Links
Biomarkers of environmental toxicity and susceptibility in autism.
Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Nataf R, Geier MR.
Institute of Chronic Illnesses, Inc., Silver Spring, Maryland, USA; CoMeD, Inc., Silver Spring, Maryland, USA.
Autism spectrum disorders (ASDs) may result from a combination of genetic/biochemical susceptibilities in the form of a reduced ability to excrete mercury and/or increased environmental exposure at key developmental times. Urinary porphyrins and transsulfuration metabolites in participants diagnosed with an ASD were examined. A prospective, blinded study was undertaken to evaluate a cohort of 28 participants with an ASD diagnosis for Childhood Autism Rating Scale (CARS) scores, urinary porphyrins, and transsulfuration metabolites. Testing was conducted using Vitamin Diagnostics, Inc. (CLIA-approved) and Laboratoire Philippe Auguste (ISO-approved). Participants with severe ASDs had significantly increased mercury intoxication-associated urinary porphyrins (pentacarboxyporphyrin, precoproporphyrin, and coproporphyrin) in comparison to participants with mild ASDs, whereas other urinary porphyrins were similar in both groups. Significantly decreased plasma levels of reduced glutathione (GSH), cysteine, and sulfate were observed among study participants relative to controls. In contrast, study participants had significantly increased plasma oxidized glutathione (GSSG) relative to controls. Mercury intoxication-associated urinary porphyrins were significantly correlated with increasing CARS scores and GSSG levels, whereas other urinary porphyrins did not show these relationships. The urinary porphyrin and CARS score correlations observed among study participants suggest that mercury intoxication is significantly associated with autistic symptoms. The transsulfuration abnormalities observed among study participants indicate that mercury intoxication was associated with increased oxidative stress and decreased detoxification capacity.


Presentation Abstract                 


Program#/Poster#:        26.5/B47
Title:        The effect of thimerosal on growth cone motility and cytoskeleton
Location:        Washington Convention Center: Hall A-C
Presentation Time:        Saturday, Nov 15, 2008, 1:00 PM - 2:00 PM
Authors:        B. NILAND, *E. A. WELNHOFER; Dept Biol, Canisius Col., Buffalo, NY
Abstract:        We investigated the neurotoxic potential of thimerosal, a mercury derived compound used in vaccines, on axon growth using cultured neurons from Helisoma trivalis. To determine the effect of thimerosal exposure (0.5-1.0 &micro;M) on axon outgrowth, we compared growth cone dynamics of the same neurons during a 20 min interval prior to and after addition of thimerosal to the culture medium. Time-lapse DIC microscopy showed thimerosal exposure inhibits growth cone advance, causing retraction of the peripheral and central domain, and an overall decrease in growth cone area. The average change in length of filopods during 20 min thimerosal exposure increased 4 fold, due to distal end growth of filopodia and lamellipodia retraction. We investigated the cytoskeletal basis for inhibition of growth cone advance by examining the immediate effects of thimerosal exposure on growth cone microtubules and F-actin. Neurons were exposed to 0.5-1 &micro;M thimerosal for 5 min before fixation and staining with tubulin antibodies and fluorescently-labeled phalloidin. Using fluorescence microscopy, the distribution of microtubules in growth cones was assessed by measuring the density of microtubules in the peripheral domain and position of microtubule ends/ size of growth cone. Within 5 min, thimerosal caused a significant decrease in microtubule density in the growth cone peripheral domain and retraction of microtubules towards the axon. The changes in microtubule distribution occurred without any significant changes in F-actin distribution in the lamellipodia or filopodial regions. These results suggest that thimerosal may inhibit axon growth by affecting microtubule dynamics within growth cones.
Autistic-like behavioral abnormalities in mice exposed to the Brick Township chemical triad Location: Washington Convention Center: Hall A-C Presentation Time: Monday, Nov 17, 2008, 1:00 PM - 2:00 PM Authors: *S. GUARIGLIA, E. C. JENKINS, Jr., C. P. CORBO, M. H. LEE, E. JENKINS, G. Y. WEN;
Inst. for Basic Res., Staten Island, NY Abstract: In 2000, the Agency for Toxic Substances and Disease Registry (ATDSR) reported that water chlorination byproducts, specifically the trihalomethanes chloroform and bromoform (THMs), as well as perchloroethylene (PCE), were found to be elevated in the drinking water of persons living in Brick Township, New Jersey, an area with a high prevalence of Autistic Spectrum Disorders. The timing of elevations in THM and PCE concentrations was concurrent with an increase in autism prevalence in this township that was 25% greater than the national increase in autism prevalence. Therefore, to investigate the effects of these chemicals on neurodevelopment, CD-1 mice were exposed to a one fold (1X), ten fold (10x), or one hundred fold (100x) concentration of the aforementioned chemical triad and remained on treatment until pups completed weaning. Male pups in the 100x group showed a significant decrease in the number of vocalizations made when compared to control group pups (p < 0.05). Experimental females showed no differences in vocalization. Male pups in all experimental groups evidenced an increase in anxiety behavior based upon a significant decrease in time spent in the open arms of an elevated plus maze when compared to controls (p < 0.05). Females evidenced no significant differences. Males in all experimental groups evidenced a significant increase in perseverance behavior in a reverse learning water T maze task when compared to controls (p < 0.05). Female mice evidenced no significant differences. These data provide evidence that THM and PCE exposure during neurodevelopment results in behavioral phenotypes that are characteristic of autism. Furthermore, females were not affected by the chemical treatment, indicating that males are more susceptible to behavioral abnormalities induced by the toxin exposure. Further investigation is necessary to ascertain which biochemical mechanisms are disrupted by the chemical treatment.
14#
发表于 2009-3-16 17:53:16 | 只看该作者

re:太难,头晕

太难,头晕
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13#
发表于 2009-2-18 05:48:46 | 只看该作者

re:受不了看这么多的英文,真佩服秋爸爸的耐心...

受不了看这么多的英文,真佩服秋爸爸的耐心.
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12#
发表于 2009-2-18 05:42:50 | 只看该作者

re:受不了

受不了
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11#
发表于 2009-2-17 21:10:40 | 只看该作者

re:感谢楼上抬举,握手。不过我无力翻那么多。...

感谢楼上抬举,握手。不过我无力翻那么多。有人建议可用谷歌翻译试试。
同是双胞胎家长,我当然要尽可能地表示一下,也只能先挑5楼给的最后的,几个近期行为训练方面的研究论文,把标题翻翻,随手意译且不保准确,有兴趣有疑惑的,应自己去找原文,J ABA就是网上免费的。

特别提醒:
我这样做目的,并非推荐大家去读那些论文,只是示例专业研究人员在做得哪些事情。事实上这类论文成千上万,读不完的,作为家长,若都上心都去读都去试,反而准保会抓瞎,还是找几本系统的书(置顶处有推荐)看看更好。

J Appl Behav Anal. 2008 Summer;41(2):237-41. Links
Using joint activity schedules to promote peer engagement in preschoolers with autism.
以一对一的结伴形式,利用“共同活动日程表”来促进学前自闭儿的同伴交往

J Autism Dev Disord. 2008 Oct;38(9):1758-66. Epub 2008 Jul 1.   Links
The effects of improvisational music therapy on joint attention behaviors in autistic children: a randomized controlled study.
“即兴音乐疗法”促进学前自闭儿的共同关注。

J Appl Behav Anal. 2008 Spring;41(1):107-11.   Links
Reducing rapid eating in teenagers with autism: use of a pager prompt.
利用寻呼机辅助来改善3个自闭症少年进食过快的行为

Singapore Med J. 2008 Mar;49(3):215-20.   Links
Effects of cognitive-behavioural therapy on anxiety for children with high-functioning autistic spectrum disorders.
6个11岁高功能ASD,经过“认知-行为疗法”训练,降低了焦虑

J Appl Behav Anal. 2007 Winter;40(4):761-5.   Links
The effects of blocking mouthing of leisure items on their effectiveness as reinforcers.
以玩具作为训练强化物事时,自闭儿常有刻板玩法,2个矫治案例且不影响该强化物的训练效力。

J Appl Behav Anal. 2007 Winter;40(4):703-6.   Links
Effects of three-step prompting on compliance with caregiver requests.
训练家长执行“三步辅助法”,从而有效地教孩子遵从

Autism. 2008 Jan;12(1):83-98.   Links
Improving question asking in high-functioning adolescents with autism spectrum disorders: effectiveness of small-group training.
9个青春期高功能ASD孩子通过小组训练提高问问题的能力

Autism. 2008 Jan;12(1):47-63.   Links
Maternal involvement in the education of young children with autism spectrum disorders.
父母参与训练的重要性

J Autism Dev Disord. 2008 Jul;38(6):1124-35. Epub 2007 Dec 7.   Links
Social interaction and repetitive motor behaviors.
社会化互动的技能学习,可降低重复性刻板动作行为。

J Intellect Dev Disabil. 2007 Dec;32(4):279-90.   Links
Developing social interaction and understanding in individuals with autism spectrum disorder: a groupwork intervention.
“集体合作”干预,提升高功能ASD社会化互动和理解技能。

J Autism Dev Disord. 2008 Jul;38(6):1092-103. Epub 2007 Nov 20.   Links
Parenting stress reduces the effectiveness of early teaching interventions for autistic spectrum disorders.
65个家庭按父母的焦虑程度分为4等,父母的紧张会降低自闭儿早期干预的效果

Am J Ment Retard. 2007 Nov;112(6):418-38.   Links
Early intensive behavioral intervention: outcomes for children with autism and their parents after two years.
早期密集行为干预2年后的明显效果,23个发育障碍孩子(对照组21个)
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10#
发表于 2009-2-4 23:18:41 | 只看该作者

re:秋爸爸能帮忙翻译一下吗?我在网上看过您两...

秋爸爸能帮忙翻译一下吗?我在网上看过您两个小孩的情况,宝宝好像恢复得很不错,我想问一下贝贝现在的情况。我自己比较倒霉,同卵双胞胎,居然哥哥不会,弟弟会。现在正在头痛怎么训练,因为小孩根本好像听不懂我们的话,或者说不理我们。
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9#
发表于 2008-12-30 19:21:14 | 只看该作者

re:“我看咱们还是说母语吧!Nice to...

“我看咱们还是说母语吧!Nice to meet you!”
   --《非诚勿扰》
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8#
发表于 2008-12-27 02:06:05 | 只看该作者

re:wo ye shi hao shi wa...

wo ye shi hao shi wang !you mei you fan yi hao de?谢谢
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7#
发表于 2008-12-26 22:14:43 | 只看该作者

re:呵呵,这是给中国人看的吗?

呵呵,这是给中国人看的吗?
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6#
 楼主| 发表于 2008-12-23 12:51:35 | 只看该作者

re:Immediate effect of...

Immediate effect of Ayres's sensory integration-based occupational therapy intervention on children with autism spectrum disorders.
Watling RL, Dietz J.
Division of Occupational Therapy, Department of Rehabilitation Medicine, University of Washington, Seattle, USA. rwatling@u.washington.edu
OBJECTIVE: This study examined the effects of Ayres' sensory integration intervention on the behavior and task engagement of young children with autism spectrum disorders (ASD). Clinical observations and caregiver reports of behavior and engagement also were explored to help guide future investigations. METHOD: This single-subject study used an ABAB design to compare the immediate effect of Ayres's sensory integration and a play scenario on the undesired behavior and task engagement of 4 children with ASD. RESULTS: No clear patterns of change in undesired behavior or task management emerged through objective measurement. Subjective data suggested that each child exhibited positive changes during and after intervention. CONCLUSION: When effects are measured immediately after intervention, short-term Ayres's sensory integration does not have a substantially different effect than a play scenario on undesired behavior or engagement of young children with ASD. However, subjective data suggest that Ayres's sensory integration may produce an effect that is evident during treatment sessions and in home environments.
PMID: 17944295
Autism. 2007 Sep;11(5):397-411.   Links
Evaluation of the relationship development intervention program.
Gutstein SE, Burgess AF, Montfort K.
The Connections Center, Houston, Texas 77025, USA. gutstein@rdiconnect.com
This study is the second in a series evaluating the effectiveness of Relationship Development Intervention (RDI) to address unique deficits inherent in autism spectrum disorders. RDI is a parent-based, cognitive-developmental approach, in which primary caregivers are trained to provide daily opportunities for successful functioning in increasingly challenging dynamic systems. This study reviewed the progress of 16 children who participated in RDI between 2000 and 2005. Changes in the Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R), flexibility, and school placement were compared prior to treatment and at a minimum 30 month follow-up period. While all children met ADOS/ADI-R criteria for autism prior to treatment, no child met criteria at follow-up. Similar positive results were found in relation to flexibility and educational placement. Generalizability of current findings is limited by the lack of a control or comparison group, constraints on age and IQ of treated children, parent self-selection, and parent education conducted through a single clinic setting.
PMID: 17942454 [P
J Altern Complement Med. 2007 Sep;13(7):709-12.   Links
Comment in:
J Altern Complement Med. 2007 Sep;13(7):695-6.
Effect of long-term interactive music therapy on behavior profile and musical skills in young adults with severe autism.
Boso M, Emanuele E, Minazzi V, Abbamonte M, Politi P.
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy. m_boso@yahoo.it
BACKGROUND: Data on the potential behavioral effects of music therapy in autism are scarce. OBJECTIVE: The aim of this study was to investigate whether a musical training program based on interactive music therapy sessions could enhance the behavioral profile and the musical skills of young adults affected by severe autism. METHODOLOGY: Young adults (N = 8) with severe (Childhood Autism Rating Scale >30) autism took part in a total of 52 weekly active music therapy sessions lasting 60 minutes. Each session consisted of a wide range of different musical activities including singing, piano playing, and drumming. Clinical rating scales included the Clinical Global Impression (CGI) scale and the Brief Psychiatric Rating Scale (BPRS). Musical skills-including singing a short or long melody, playing the C scale on a keyboard, music absorption, rhythm reproduction, and execution of complex rhythmic patterns-were rated on a 5-point Likert-type scale ranging from "completely/entirely absent" to "completely/entirely present." RESULTS: At the end of the 52-week training period, significant improvements were found on both the CGI and BPRS scales. Similarly, the patients' musical skills significantly ameliorated as compared to baseline ratings. CONCLUSIONS: Our pilot data seem to suggest that active music therapy sessions could be of aid in improving autistic symptoms, as well as personal musical skills in young adults with severe autism.
PMID: 17931062
J Autism Dev Disord. 2008 Apr;38(4):771-5. Epub 2007 Aug 21.   Links
Case report: Using an auditory trainer with caregiver video modeling to enhance communication and socialization behaviors in autism.
Baharav E, Darling R.
Department of Communication Sciences and Disorders, Western Washington University, 516 High Street, Bellingham, WA 98225-9078, USA. eva.baharav@wwu.edu
A minimally verbal child with autism was exposed to short daily sessions of watching his parents on video in conjunction with an FM auditory trainer for a period of 4 weeks. Baseline measures of verbal and social behaviors were taken pre-treatment and repeated post treatment. Results indicate substantial gains in word productions, social orienting, and increased eye contact. Results are discussed in terms of the contributions of auditory-visual processing to establishing communication and socialization in autism and early intervention effectiveness.
PMID: 17710521
J Dev Behav Pediatr. 2007 Aug;28(4):308-16.   Links
A randomized, controlled trial of a home-based intervention program for children with autism and developmental delay.
Rickards AL, Walstab JE, Wright-Rossi RA, Simpson J, Reddihough DS.
Murdoch Childrens Research Institute, Royal Children's Hospital, University of Melbourne, Parkville, Australia. rickards1@bigpond.com
OBJECTIVE: This study aimed to (1) investigate whether provision of a home-based program in addition to a center-based program improves development in young children with disabilities and coping abilities of their families and (2) describe the characteristics of children and families who benefit most from the intervention. METHODS: Fifty-nine children, aged 3-5 years, with no cerebral palsy, participated in the study. Half of the group was randomized to receive an additional program in their homes. A special education teacher provided 40 visits over 12 months working with the families to help generalize skills to the home environment and assist with their concerns. All children were assessed before and after the intervention, and families completed questionnaires assessing family stress, support, and empowerment on both occasions. Differences in change over time and between the intervention and control group were analyzed by repeated measures and the association between characteristics of children and families with improved outcome by multivariate analysis of variance. RESULTS: Change in cognitive development and behavior (in the centers) over time favored the children who received the extra intervention (p = .007 and p = .007, respectively). The groups did not differ on any of the family measures of change. Multivariate analysis of variance revealed more improvement for children in the intervention group from higher than lower stressed families. CONCLUSIONS: Results suggest the need for daily reinforcement of skills learned at the center-based program and the importance of involving families, especially those with few resources and relatively high stress.
PMID: 17700083
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5#
 楼主| 发表于 2008-12-23 12:51:26 | 只看该作者

re:9. Social Skills Gro...

9. Social Skills Groups
Therapy sessions that provide didactic instruction to high-functioning children with autism spectrum disorders on social skills.
Examples: Social skills training, Theory of Mind Training, summer camp program
Research Summary: Preliminary evidence indicates that high-functioning children with autism spectrum disorders who participate in social skills groups may increase their awareness of social cues and their understanding of how to interact appropriately with peers, but they may have difficulty learning to apply this knowledge in the context of everyday situations. Additional research with strong experimental designs is needed to confirm these findings.
Recommendations:An important area for future research is to evaluate social skills groups in studies with strong experimental designs. It also will be important to develop strategies to help children with autism spectrum disorders generalize skills from therapy groups to everyday situations. Professionals should present social skills groups as having limited scientific support, encourage families who are considering this intervention to use it in conjunction with other teaching methods, and recommend careful evaluation of the intervention.
Selected References:
Selected scientific studies:
•        Lopata, C., Thomeer, M. L., Volker, M. A., &amp; Nida, R. E. (2006). Effectiveness of a cognitive-behavioral treatment on the social behaviors of children with asperger disorder. Focus on Autism and Other Developmental Disabilities, 21(4), 237-244.
•        Ozonoff, S., &amp; Miller, J. N. (1995). Teaching theory of mind: A new approach to social skills training for individuals with autism. Journal of Autism and Developmental Disorders, 25, 415–433.
•        Solomon, M., Goodlin-Jones, B. L., &amp; Anders, T. F. (2004). A social adjustment enhancement intervention for high functioning autism, Asperger’s Syndrome, and Pervasive Developmental Disorder NOS. Journal of Autism and Developmental Disorders, 34, 649–668.
Systematic reviews:
•        White, S. W., Koenig, K., &amp; Scahill, L. S. (2007). Social skills development in children with autism spectrum disorders: A review of the intervention research.
10. Social Stories
Description: A story written according to specific guidelines to describe a situation in terms of relevant cues and common responses. Social stories are usually written for individual students, reflecting on the student’s perception of a situation.
Examples: Comic strip conversations, Thinking stories, or Story boxes
Research Summary: Preliminary evidence indicates that social stories may be effective in reducing problem behavior or improving adaptive behavior, particularly when used in conjunction with applied behavior analytic teaching methods. To benefit from this approach, individuals with autism spectrum disorders may need to be able to communicate in sentences that connect different ideas to each other.
Recommendations: An important area for future research is to evaluate social stories in studies with strong experimental designs. Professionals should present social stories as having limited scientific support, encourage families who are considering this intervention to use it in conjunction with other teaching methods, and recommend careful evaluation of the intervention.
Selected References:
Selected scientific studies:
•        Scattone, D., Tingstrom, D. H., &amp; Wilczynski, S. M. (2006). Increasing appropriate social interactions of children with autism spectrum disorders using social stories. Focus on Autism and Other Developmental Disabilities, 21, 211-222.
•        Scattione, D., Wilczynski, S. M., &amp; Edwards, R. P.(2002). Decreasing disruptive behaviors of children with autism using social stories. Journal of Autism and Developmental Disorders, 32, 535-543.
•        Thiemann, K. S., &amp; Goldstein, H. (2001). Social stories, written text cues, and video feedback: Effects on social communication of children with autism. Journal of Applied Behavior Analysis, 34, 425-446.
Systematic reviews:
•        Reynhout, G., &amp; Carter, M. (2006). Social Stories for children with disabilities. Journal of Autism and Developmental Disorders, 36, 445-469.
11. Video Modeling
Description: An ABA teaching method used to develop and strengthen communication skills, academic performance, and social and self-help skills. The targeted behaviors that the child is to learn are videotaped. Then the child watches the video and is given the chance to memorize, imitate and generalize those behaviors.
Examples: Computer Animated Learning or Video Instruction
Research Summary: Video modeling is a well-established teaching method in applied behavior analysis for individuals with autism spectrum disorders. It is supported by numerous well-designed studies.
Recommendations: Video modeling is a useful intervention for teaching social, play, and self-help intervention to individuals with autism spectrum disorders who have well-developed imitation skills.
Selected References:
Systematic reviews of scientific studies:
•        Bellini, S., &amp; Akullian, J. (2007). A meta-analysis of video modeling and video self-modeling interventions for children and adolescents with autism spectrum disorders. Exceptional children, 73(3), 264-287.
•        Corbett, B. A., &amp; Abdullah, M. (2005). Video modeling: Why does it work for children with autism? Journal of Early Intensive Behavioral Intervention, 2, 2-8.
  
J Appl Behav Anal. 2008 Summer;41(2):237-41. Links
Using joint activity schedules to promote peer engagement in preschoolers with autism.
Betz A, Higbee TS, Reagon KA.
Utah State University, Logan, Utah 84322, USA.
We assessed the use of a joint activity schedule to increase peer engagement for preschoolers with autism. We taught 3 dyads of preschoolers with autism to follow joint activity schedules that cued both members of the pair to play a sequence of interactive games together. Results indicated that joint activity schedules increased peer engagement and the number of games completed for all dyads. Schedule following was maintained without additional prompting when activities were resequenced and when new games were introduced for 2 of the 3 dyads.
PMID: 18595287 [PubMed - indexed for MEDLINE]
J Autism Dev Disord. 2008 Oct;38(9):1758-66. Epub 2008 Jul 1.   Links
The effects of improvisational music therapy on joint attention behaviors in autistic children: a randomized controlled study.
Kim J, Wigram T, Gold C.
Aalborg University, Aalborg, Denmark. jinahkim@jj.ac.kr
The purpose of this study was to investigate the effects of improvisational music therapy on joint attention behaviors in pre-school children with autism. It was a randomized controlled study employing a single subject comparison design in two different conditions, improvisational music therapy and play sessions with toys, and using standardized tools and DVD analysis of sessions to evaluate behavioral changes in children with autism. The overall results indicated that improvisational music therapy was more effective at facilitating joint attention behaviors and non-verbal social communication skills in children than play. Session analysis showed significantly more and lengthier events of eye contact and turn-taking in improvisational music therapy than play sessions. The implications of these findings are discussed further.
J Appl Behav Anal. 2008 Spring;41(1):107-11.   Links
Reducing rapid eating in teenagers with autism: use of a pager prompt.
Anglesea MM, Hoch H, Taylor BA.
Alpine Learning Group, Paramus, New Jersey 07652 , USA.
This study assessed the effects of a vibrating pager for increasing the duration of meal consumption in 3 teenagers with autism who were observed to eat too quickly. Participants were taught to take a bite only when the pager vibrated at predetermined intervals. A reversal design indicated that the vibrating pager successfully increased the total duration of mealtime, thereby slowing the pace of consumption for all 3 participants.
PMID: 18468283
Singapore Med J. 2008 Mar;49(3):215-20.   Links
Effects of cognitive-behavioural therapy on anxiety for children with high-functioning autistic spectrum disorders.
Ooi YP, Lam CM, Sung M, Tan WT, Goh TJ, Fung DS, Pathy P, Ang RP, Chua A.
Department of Child and Adolescent Psychiatry, Institute of Mental Health, Child Guidance Clinic, Health Promotion Board, 3 Second Hospital Avenue #03-01, Singapore 168937.
INTRODUCTION: Children with autistic spectrum disorders (ASD) often exhibit one or more comorbid disorders, including anxiety, disruptive behaviour, mental retardation, and depression. Various studies have documented the effectiveness of cognitive-behavioural therapy (CBT) in treating children with anxiety. Although studies have indicated a high prevalence of anxiety in individuals with ASD, there is a lack of systematic studies substantiating the effectiveness of cognitive-behavioural interventions among children with high-functioning autism. METHODS: This pilot study investigated the effects of a 16-session CBT programme on six high-functioning children diagnosed with ASD (mean age 11.50 years, standard deviation 0.84 years). These children were diagnosed with ASD or Asperger's syndrome by the DSM-IV criteria. Measures on levels of child's anxiety, parental and teacher stress were administered at pre- and post-treatment. RESULTS: Children showed lower levels of anxiety at post-treatment. Parents and teachers also reported lower levels of stress following the CBT programme. CONCLUSION: Findings from the present study provided some evidence of the effects of CBT for high-functioning autistic children in reducing anxiety, parental and teacher stress. Interpretation of the findings, recommendations for future research and implications of the present study are presented.
PMID: 18363003 [P
J Appl Behav Anal. 2007 Winter;40(4):761-5.   Links
The effects of blocking mouthing of leisure items on their effectiveness as reinforcers.
Tarbox RS, Tarbox J, Ghezzi PM, Wallace MD, Yoo JH.
California State University, Los Angeles, USA.
Leisure items are commonly used as reinforcers in behavior-analytic applications. However, a defining feature of autism is the occurrence of stereotypy, and individuals with autism often engage leisure items in a stereotyped manner. The opportunity for stereotyped interaction may be the only aspect of a contingent stimulus that makes it a reinforcer for appropriate behavior. Therefore, this study investigated the effects of blocking stereotyped reinforcer interaction on reinforcer efficacy for 2 children with autism. Results showed that blocking stereotypic reinforcer interaction did not influence reinforcer efficacy.
PMID: 18189113 [PubMed - indexed for MEDLINE]
J Appl Behav Anal. 2007 Winter;40(4):703-6.   Links
Effects of three-step prompting on compliance with caregiver requests.
Tarbox RS, Wallace MD, Penrod B, Tarbox J.
University of Nevada, Reno, USA.
Three-step prompting is a procedure commonly used in behavioral assessments and interventions; however, little research has evaluated the effects of this procedure on increasing children's compliance with caregiver requests. In this study, caregivers of children who demonstrated low levels of compliance were trained to use three-step prompting when presenting task requests to their children. Results indicated that training caregivers to implement this procedure decreased the frequency of caregiver-delivered prompts and increased compliance by the children.
PMID: 18189103 [PubMed - indexed for MEDLINE]
Autism. 2008 Jan;12(1):83-98.   Links
Improving question asking in high-functioning adolescents with autism spectrum disorders: effectiveness of small-group training.
Palmen A, Didden R, Arts M.
Dr Leo Kannerhuis Doorwerth, The Netherlands. A.Palmen@pwo.ru.nl
Small-group training consisting of feedback and self-management was effective in improving question-asking skills during tutorial conversations in nine high-functioning adolescents with autism spectrum disorder. Training was implemented in a therapy room and lasted 6 weeks. Sessions were conducted once a week and lasted about an hour. Experimenters collected data during tutorial conversations in a natural setting. Training of question-asking skills consisted of verbal feedback and role-play during short simulated conversations and a table game. A self-management strategy and common stimuli (e.g., flowchart) were included to promote generalization. Mean percentage of correct questions during tutorial conversations improved significantly after training. Response efficiency also increased. Participants and personal coaches evaluated the training as effective and acceptable.
PMID: 18178598
Autism. 2008 Jan;12(1):47-63.   Links
Maternal involvement in the education of young children with autism spectrum disorders.
Benson P, Karlof KL, Siperstein GN.
University of Massachusetts, Boston, MA 02125, USA. paul.benson@umb.edu
Parent involvement is widely acknowledged to be a critical ;best practice' in the education of young children with ASD. Despite its importance, no studies to date have systematically examined the relative influence of child, family, and school factors on the extent to which parents participate in the education of their children with ASD. In the present study, questionnaire and interview data collected from the mothers and teachers of 95 children receiving public school services for ASD were used to address this issue. Descriptively, wide variation was found in both type and intensity of mothers' educational involvement. Regression analyses showed involvement, both at school and at home, to be heavily influenced by the extent to which school staff actively encouraged, assisted, and provided opportunities for parent involvement. In addition, severity of child behavior problems was also found to exert a uniformly negative effect on intensity of mothers' educational involvement, while the influence of family resources and demand variables varied, depending on whether involvement occurred at school or at home. Implications of these findings for future research and for the support of parents seeking to participate in the learning and development of their children with ASD are discussed.
PMID: 18178596
: J Autism Dev Disord. 2008 Jul;38(6):1124-35. Epub 2007 Dec 7.   Links
Social interaction and repetitive motor behaviors.
Loftin RL, Odom SL, Lantz JF.
Yale Child Study Center, Yale School of Medicine, New Haven, CT, USA. rloftin@uic.edu
Students with autism have difficulty initiating social interactions and may exhibit repetitive motor behavior (e.g., body rocking, hand flapping). Increasing social interaction by teaching new skills may lead to reductions in problem behavior, such as motor stereotypies. Additionally, self-monitoring strategies can increase the maintenance of skills. A multiple baseline design was used to examine whether multi-component social skills intervention (including peer training, social initiation instruction, and self-monitoring) led to a decrease in repetitive motor behavior. Social initiations for all participants increased when taught to initiate, and social interactions continued when self-monitoring was introduced. Additionally, participants' repetitive motor behavior was reduced. Changes in social behavior and in repetitive motor behavior maintained more than one month after the intervention ended.
PMID: 18064552
J Intellect Dev Disabil. 2007 Dec;32(4):279-90.   Links
Developing social interaction and understanding in individuals with autism spectrum disorder: a groupwork intervention.
Mackay T, Knott F, Dunlop AW.
National Centre for Autism Studies, University of Strathclyde, UK. Tommy@ardoch.fsnet.co.uk
BACKGROUND: Difficulties with social interaction and understanding lie at the heart of the communication disorder that characterises the autism spectrum. This study sought to improve social communication for individuals with autism spectrum disorder (ASD) by means of a groupwork intervention focusing on social and emotional perspective-taking, conversation skills, and friendship skills. It also aimed to address some of the limitations of previous interventions, including a lack of generalisation to other settings, so as to maximise inclusion in the community. METHOD: A group of 46 high functioning children and adolescents with ASD (38 boys, 8 girls, age range 6-16 years) were allocated to one of 6 intervention groups. Each group met over a period of 12-16 weeks for a minimum of one 1(1/2)-hour weekly session aimed at promoting key areas of social interaction and understanding, supported by home-based practice. RESULTS: Significant gains were achieved in comparison with a normative population, and individual parent ratings showed marked and sustained changes in the key areas targeted in the group sessions. CONCLUSION: Social communication in children and adolescents with ASD can be enhanced through the use of a groupwork intervention addressing social interaction and understanding.
PMID: 18049972
J Autism Dev Disord. 2008 Jul;38(6):1092-103. Epub 2007 Nov 20.   Links
Parenting stress reduces the effectiveness of early teaching interventions for autistic spectrum disorders.
Osborne LA, McHugh L, Saunders J, Reed P.
Department of Psychology, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
This community-based study examined the influence of early teaching interventions on children diagnosed with Autistic Spectrum Disorders, and the dynamics between the time intensity of the interventions and parenting stress, on child outcomes. Intellectual, educational, and adaptive behavior and social functioning were all measured. Sixty-five children were divided into four groups, based on the levels of time intensity of their intervention, and on their parents' stress levels. There were gains in intellectual, educational, and adaptive behavioral and social skills, and there was a positive relationship between the time intensity of the early teaching interventions and child outcome gains. More importantly, however, high levels of parenting stress counteracted the effectiveness of the early teaching interventions.
PMID: 18027079 [
Am J Ment Retard. 2007 Nov;112(6):418-38.   Links
Early intensive behavioral intervention: outcomes for children with autism and their parents after two years.
Remington B, Hastings RP, Kovshoff H, degli Espinosa F, Jahr E, Brown T, Alsford P, Lemaic M, Ward N.
Centre for Behavioural Research Analysis and intervention in Developmental Disabilities, School of Psychology, University of Southampton, UK. rer1@soton.ac.uk
An intervention group (n=23) of preschool children with autism was identified on the basis of parent preference for early intensive behavioral intervention and a comparison group (n=21) identified as receiving treatment as usual. Prospective assessment was undertaken before treatment, after 1 year of treatment, and again after 2 years. Groups did not differ on assessments at baseline but after 2 years, robust differences favoring intensive behavioral intervention were observed on measures of intelligence, language, daily living skills, positive social behavior, and a statistical measure of best outcome for individual children. Measures of parental well-being, obtained at the same three time points, produced no evidence that behavioral intervention created increased problems for either mothers or fathers of children receiving it.
PMID: 17963434
Am J Occup Ther. 2007 Sep-Oct;61(5):574-83. Links
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 楼主| 发表于 2008-12-23 12:50:49 | 只看该作者

re:Association for Scie...

Association for Science in Autism Treatment (http://www.asatonline.org)
The Association for Science in Autism Treatment has what I believe was the best scientific evaluations of learning interventions used in the USA in an attempt to treat autism. The Association appears to review available scientific data and make a conclusion of whether the learning intervention has (1) proof it works, (2) suggestion that it might work, (3) no data to say it might or might not work or (4) data that indicates it does not work.

I have cut/pasted from the website the Table of Contents that identifies which types of treatment they have reviewed. After reading their reviews I then cut/pasted those treatments with likely merit. I ignored the (drug) therapeutic approaches but you might want to check these yourself.
After the ASAT section I cut/paste what I thought were relevant abstracts from the last 200 abstracts (Aug 2007 to present) after searching the US National Library of Medicine with terms “autism” and “behavioral treatment”.


Table of Contents
Psychological, Educational, and Therapeutic Interventions
•        Animal Therapy
o        Therapeutic Horseback Riding
o        Dolphin Therapy
o        Pet Therapy
•        Applied Behavior Analysis (ABA)
•        Art Therapy
•        Auditory Integration Therapy (AIT)
o        Tomatis Method
o        Berard Method
o        Fast Forward
o        Earobics
•        Augmentative and Alternative Communication (AAC)
•        Developmental Therapies
o        Developmentally-based Individual-difference Relationship-based Intervention (DIR)
o        Floor Time
o        Greenspan Method
•        Facilitated Communication
•        Glasses
•        Holding Therapy
•        Music Therapy
•        Oral-Motor Training/Therapy
o        Kaufman Method
o        Prompts for Restructuring Oral Muscular Targets (PROMPT)
o        Rosenfeld-Johnson Method
•        Patterning
•        Picture Exchange Communication System (PECS)
•        Project TEACCH (Treatment and Education of Autistic and related Communication-handicapped Children)
•        Psychoanalytic and Humanistic Play Therapy
•        Recreational Sports/Exercise
•        Relationship Development Intervention (RDI)
•        Sensory Integrative Therapy (Sensory Integration, SI, or SIT)
•        Socialization related classes
•        Social Skills Groups
•        Social Stories
•        Son Rise (Options)
•        Video Modeling
•        Vision Therapy
o        Irlen lenses
o        Glasses
o        Eye exercises
o        Rapid Eye Therapy
o        Iridology
o        Ambient lenses
o        Yoked prisms

The following behavioral approaches were considered either possibly beneficial or beneficial:
1. Applied Behavior Analysis (ABA)
Description: Practitioners of applied behavior analysis (ABA) aim to improve socially important behavior by using interventions that are based upon principles of learning theory and that have been evaluated in experiments using reliable and objective measurement. ABA methods are intended to support persons with autism spectrum disorders in many ways:
•        To increase behaviors (e.g. to increase on-task behavior, or social interactions) and to teach new skills (e.g., life skills, communication skills, or social skills);
•        To maintain behaviors (e.g., self control and self monitoring procedures to maintain and generalize job-related social skills);
•        To generalize or to transfer behavior from one situation or response to another (e.g., from completing assignments in the resource room to performing as well in the mainstream classroom);
•        To restrict or narrow conditions under which interfering behaviors occur (e.g., modifying the learning environment); and
•        To reduce interfering behaviors (e.g., self injury or stereotypy).
Research Summary: Many studies show that ABA is effective in increasing behaviors and teaching new skills (Goldstein, 2002; Odom et al., 2003; McConnell, 2002). In addition, many studies demonstrate that ABA is effective in reducing problem behavior (Horner et al., 2002). A number of studies also indicate that, when implemented intensively (more than 20 hours per week) and early in life (beginning prior to the age of 4 years), ABA may produce large gains in development and reductions in the need for special services (Smith, 1999); however, large studies with strong experimental designs are needed to confirm the results reported for intensive, early intervention.
The United States Surgeon General (1999) concluded, "Thirty years of research demonstrated the efficacy of applied behavioral methods in reducing inappropriate behavior and in increasing communication, learning and appropriate social behavior."
Recommendations: ABA is an effective intervention for many individuals with autism spectrum disorders. ABA interventions should be supervised by qualified behavior analysts. Because of the scientific support for ABA, professionals and families may wish to obtain additional information about this approach; resources are listed in the references below.
An important area for research is to conduct large studies with strong scientific designs to evaluate long-term outcomes of early, intensive ABA and other comprehensive ABA intervention programs.
Selected References:
Systematic reviews of scientific studies:
•        Goldstein, H. (2002). Communication intervention for children with autism: A review of treatment efficacy. Journal of Autism and Developmental Disorders, 32, 373-396.
•        Horner, R. H., Carr, E. G., Strain, P. S., Todd, A. W., & Reed, H. K.(2002). Problem behavior interventions for young children with autism: A research synthesis. Journal of Autism and Developmental Disorders. 32, 423-446.
•        McConnell, S. (2002).Interventions to facilitate social interaction for young children with autism: Review of available research and recommendations for educational intervention and future research. Journal of Autism and Developmental Disorders, 32, 351-372.
•        Odom, S. L., Brown, W. H., Frey, T., Karasu, N., Smith-Canter, L. L., & Strain, P. S. (2003). Evidence-based practices for young children with autism: Contributions from single-subject design research. Focus on Autism and Other Developmental Disabilities, 18, 166-175.
•        Smith, T. (1999). Outcome of early intervention for children with autism. Clinical Psychology: Science and Practice, 6, 33-49.
•        United States Surgeon General (1998). Mental health: A report of the Surgeon General. Washington, DC: Author.
Position statements from professional organizations:
•        Maine Administrators of Services for Children with Disabilities (MADSEC). (1999). Report of the MADSEC autism task force (revised ed.). Manchester, ME: Author.
•        New York State Department of Health, Early Intervention Program. (1999). Clinical practice guideline: The guideline technical report. Autism/ pervasive developmental disorders, assessment and intervention for young children (Age 0-3 Years). Albany, NY: Author.
For additional information:
•        Maurice, C. Green, G., & Luce, S. C. (Eds.). Behavioral intervention for young children with autism: A manual for parents and professionals. (pp. 45-67). Austin, TX: Pro-Ed.
•        Maurice, C., Green, G., & Foxx, R. (Eds.). Making a difference: Behavioral intervention in autism. Austin, TX: Pro-Ed.
2. Augmentative and Alternative Communication (AAC)
Description: Refers to methods of communication to either enhance or replace conventional forms of communication (spoken language). Individuals with significant impairment in communication skills may rely on augmentative communication systems to express their needs, wants, and feelings. There are a variety of augmentative communication systems that are available including gestures, sign language, picture exchange (such as PECS), pointing to pictures, and electronic devices that include voice output. Each system has unique advantages and disadvantages so the ultimate choose of a system should be predicated on a complete evaluation. Such an evaluation should consider the individual’s existing skills, his/her communication needs, and the skills needed to interact with others.
Research Summary: Studies indicate that AAC may improve communication skills for children with autism spectrum disorders who have limited or no verbal communication skills when ABA teaching methods are used to teach AAC. However, benefits appear to be limited. “Children with good verbal imitation skills demonstrate better speech production than those with poor verbal imitation skills, with or without AAC” (National Research Council, 2001, p. 58). Regarding sign language, “It is important to note that simple signs may be a support for children learning to speak or an additional mode of communication for children who have no speech or limited speech. However, it is very rare to find a child with autism spectrum disorder who learns to sign fluently (in sentences) and flexibly. Signing is not generally an entry point into a complex, flexible system” (National Research Council, 2001, p. 58). Similar findings have been reported for the Picture Exchange Communication System (see the research summary for PECS). There are case reports of children with autism spectrum disorders becoming proficient with electronic voice-output devices, but studies with strong scientific design have not been conducted on the use of such devices for children with autism spectrum disorders.
(See also the section on the Picture Exchange Communication System)
Recommendations: The application of ABA methods to teach AAC is an appropriate intervention for children with autism who have limited or no communication skills. Because of the scientific support for AAC, professionals and families may wish to obtain additional information about this approach; resources are listed in the references below.
To increase the utility of this intervention, an important area for future research is to investigate AAC methods for promoting initiation of communication and acquisition of complex, flexible language.
Selected References:
Systematic reviews of scientific studies:
•        Hourcade, J., Pilotte, T. E., West, E., & Parette, P. (2004). A history of augmentative and alternative communication for individuals with severe and profound disabilities. Focus on Autism and Other Developmental Disabilities, 19, 235-244.
•        National Research Council (2001). Educating Children with Autism. Washington DC: National Academy Press.
For additional information:
•        Beukelman, D. R., & Mirenda, P. (2005). Augmentative and alternative communication: Supporting children and adults with complex communication needs (3rd ed.). Baltimore: Paul H. Brookes.
3. Developmentally-based Individual-difference Relationship-based intervention (DIR)/Floor Time
Description: Also called Greenspan Method. In Floor Time, the adult participates with the child in his/her space. The child’s actions set the lead for actions that the adult can extend or elaborate. For example, if the child wants to line up cars in a row, the parent or service provider may playfully intrude in this activity (e.g., moving one of the cars or blocking a car and asking where it’s going). Floor Time is usually provided by parents under the direction of psychologists. However, it may be an intervention strategy used by professionals in other disciplines such as speech therapy or special education.
Research Summary: DIR is widely considered to be a plausible intervention approach (i.e., one that could be effective), but it has not been evaluated in peer-reviewed studies with strong experimental designs (National Research Council, 2001).
Recommendations: An important area for future research is to evaluate DIR in studies with strong experimental designs. Professionals should present DIR as untested and encourage families who are considering this intervention to evaluate it carefully.
Selected References:
Systematic reviews of scientific studies:
•        National Research Council (2001). Educating Children with Autism. Washington DC: National Academy Press.
4. Music Therapy
Description: Refers to the application of music with the intent to enhance functioning. It consists of using music therapeutically to address behavioral, social, psychological, communicative, physical, sensory-motor, and/or cognitive functioning. The music therapist involves clients in singing, listening, moving, playing instruments, and creative activities in a systematic, prescribed manner to influence change in targeted responses or behaviors and help clients meet individual goals and objectives.
Because musical activities may be highly preferred by an individual with autism spectrum disorder (e.g., listening to music, dancing, playing an instrument), access to such activities may be used as a reward. This is different from music therapy, in which the musical activities themselves are viewed as therapeutic.
Research Summary: Preliminary evidence suggests that music therapy could be effective in enhancing functioning (Kaplan & Steele, 2005; Whipple, 2004), but this approach has not been evaluated in studies with strong experimental designs.
Recommendations: Researchers may wish to conduct studies with strong scientific designs to evaluate music therapy. Professionals should present music therapy as untested and encourage families who are considering this intervention to evaluate it carefully.
Selected References:
Systematic reviews of scientific studies:
•        Kaplan, R. S. & Steele, A. L. (2005) An analysis of music therapy program goals and outcomes for clients with diagnoses on the autism spectrum. Journal of Music Therapy, 42(1), 2-19.
•        Whipple, J. (2004). Music in intervention for children and adolescents with autism: A meta-analysis. Journal of Music Therapy, 41, 90-105.
5. Picture Exchange Communication System (PECS)
Description: One of the methods used under an ABA approach, PECS uses pictures and other symbols to develop a functional communication system. PECS teaches students to exchange a picture of a desired item for the actual item.
Research Summary: Studies show that PECS is effective in teaching communications that involve single words or short phrases, and that gains may generalize to everyday settings. Ongoing consultation from an expert in this approach is likely to be necessary to maintain these gains.
Recommendations:The application of ABA methods to teach PECS is an appropriate intervention for children with autism spectrum disorders who have limited or no communication skills. To increase the utility of this intervention, an important area for future research is to investigate PECS procedures for promoting initiation of communication and acquisition of complex, flexible language.
Selected References:
Selected scientific studies:
•        Howlin, P., Gordon, R. K., Pasco, G., Wade, G., & Charman, T. (2007). Journal of Child Psychology & Psychiatry, 48, 473-481.
•        Yoder, P., & Stone, W. L. (2006). Randomized comparison of two communication interventions for preschoolers with autism. Journal of Consulting and Clinical Psychology, 74, 426-425.
For additional information:
•        Bondy, A. & Frost, L. (2001). The Picture Exchange Communication System. Behavior Modification, 25, 725-744.
6. Project TEACCH (Treatment and Education of Autistic and related Communication-handicapped CHildren)
Description : In TEACCH, children and adults with autism spectrum disorders receive individual classroom instruction designed to accommodate learning styles characteristic of autism spectrum disorders. For example, because visual skills tend to be more advanced than verbal skills, instructions may be presented in pictures rather than words, and tasks may have visual prompts (e.g., grooves to indicate where to place items, pictures of each step of the task, etc.). Because classroom noise or intrusions from peers may be distracting or aversive, individuals with autism spectrum disorders often work at their own workstations rather than with classmates, though small group instruction also occurs. Because transitions from one activity to another may be difficult, individuals with autism spectrum disorders may have a highly structured schedule placed at their workstations.
Research Summary: TEACCH is widely considered to be a plausible intervention approach (i.e., one that could be effective; National Research Council, 2001). One small but well-designed study indicated that parent training provided by TEACCH may accelerate the development of cognitive and self-help skills (Ozonoff & Cathcart, 1998). Another small study indicated that TEACCH workstations may increase on-task behavior and completion of assignments (Hume & Odom, 2007). Other aspects of TEACCH such as classroom instruction have support from preliminary studies (e.g., Lord & Schopler, 1989) but have not been evaluated in peer-reviewed studies with strong experimental designs.
Recommendations: An important area for future research is to evaluate TEACCH in studies with strong experimental designs. Professionals should present TEACCH as untested and encourage families who are considering this intervention to evaluate it carefully.
Selected References:
Selected scientific studies:
•        Lord, C., & Schopler, E. (1989). The role of age at assessment, developmental level, and test in the stability of intelligence scores in young autistic children. Journal of Autism & Developmental Disorders. 19, 483-499.
•        National Research Council (2001). Educating Children with Autism. Washington DC: National Academy Press.
•        Ozonoff, S., & Cathcart, K. (1998). Effectiveness of a home program intervention for young children with autism. Journal of Autism & Developmental Disorders, 28, 25-32.
•        Hume, K., & Odom, S. (2007). Effects of an individual work system on the independent functioning of students with autism. Journal of Autism & Developmental Disorders, 37, 1166-1180.
Systematic Reviews:
•        National Research Council (2001). Educating Children with Autism. Washington DC: National Academy Press.
7. Recreational Sports/Exercise
Description: Attendance at sports classes such as swimming, gymnastics, or martial arts to give the child opportunities to develop athletic skills and interact, participate in group activities, and interact with other children.
Research Summary: Recreational sports may be a healthy and enjoyable activity, affording opportunities to generalize skills learned in therapy or school programs. However, their effects have not been evaluated in scientific studies with strong experimental designs.
Antecedent exercise, in which an individual exercises on a regular schedule, may reduce aggression or repetitive behaviors for some individuals with autism spectrum disorders (Celiberti, Bobo, Kelly, Harris, & Handleman, 1997; Rosenthal-Malek & Mitchell, 1997).
Some studies suggest that simply placing children with autism spectrum disorders in settings with typical peers, without any other intervention, may increase their social interactions (Lord & Hopkins, 1986) and reduce their repetitive behaviors (McGee, Paradis, & Feldman, 1993), but other studies have not shown these effects (Strain, 1983). Thus, additional research is needed on whether simply placing children with autism spectrum disorders in settings with typical peers is effective. However, there is strong evidence from multiple studies that placing children with autism spectrum disorders in settings with typically developing peers who have been taught to serve as tutors or models is effective in increasing social interactions (McConnell, 2002).
Recommendations: Recreational sports may have health benefits, may be an enjoyable leisure activity for individuals with autism spectrum disorders, and, in some cases, may help prevent problem behavior such as aggression. Sports also may afford opportunities for socialization, particularly if peers who have been taught to serve as tutors or models are available during the activity.
Selected References:
Selected scientific studies:
•        Lord, C., & Hopkins, J. M. (1986). The social behavior of autistic children with younger and same-age nonhandicapped peers. Journal of Autism and Developmental Disorders, 16, 249-262.
•        Celiberti, D. A., Bobo, H. E., Kelly, K. S., Harris, S. L., & Handleman, J. L. (1997). The differential and temporal effects of antecedent exercise on the self-stimulatory behavior of a child with autism. Research in Developmental Disabilities, 18, 139-150.
•        McGee, G. G., Paradis, T., & Feldman, R. S. (1993). Free effects of integration on levels of autistic behavior. Topics in Early Childhood Special Education, 13, 57-67.
•        Rosenthal-Malek, A., & Mitchell, S. (1997). The effects of exercise on the self-stimulatory behaviors and positive responding of adolescents with autism. Journal of Autism and Developmental Disorders, 27, 193-202.
•        Strain, P. S. (1983). Generalization of autistic children’s social behavior change: Effects of developmentally integrated and segregated settings. Analysis and Intervention in Developmental Disabilities, 3, 23-34.
Systematic reviews of scientific studies:
•        McConnell, S. (2002). Interventions to facilitate social interaction for young children with autism: Review of available research and recommendations for educational intervention and future research. Journal of Autism and Developmental Disorders, 32, 351-372.
8. Socialization related classes
Description: Attendance at classes in the community to give the child opportunities to participate in group activities and interact with other children. Socialization classes are different from an integrated preschool, where therapeutic and special education services are delivered in a typical educational classroom.
Examples: Mommy and Me class, Gymboree, or Private preschool
Research Summary: Socialization related classes may be an enjoyable recreational activity, affording opportunities to generalize skills learned in therapy or school programs. However, their effects have not been evaluated in scientific studies with strong experimental designs.
Some studies suggest that simply placing children with autism spectrum disorders in settings with typical peers, without any other intervention, may increase their social interactions (Lord & Hopkins, 1986) and reduce their repetitive behaviors (McGee, Paradis, & Feldman, 1993), but other studies have not shown these effects (Strain, 1983). Thus, additional research is needed on whether simply placing children with autism in settings with typical peers is effective. However, there is strong evidence from multiple studies that placing children with autism spectrum disorders in settings with typically developing peers who have been taught to serve as tutors or models is effective in increasing social interactions (McConnell, 2002).
Recommendations: Socialization-related classes may be an enjoyable leisure activity for individuals with autism spectrum disorders. They also may afford opportunities for socialization, particularly if peers who have been taught to serve as tutors or models are available during the activity.
Selected References:
Selected scientific studies:
•        Lord, C., & Hopkins, J. M. (1986). The social behavior of autistic children with younger and same-age nonhandicapped peers. Journal of Autism and Developmental Disorders, 16, 249-262.
•        McGee, G. G., Paradis, T., & Feldman, R. S. (1993). Free effects of integration on levels of autistic behavior. Topics in Early Childhood Special Education, 13, 57-67.
•        Strain, P. S. (1983). Generalization of autistic children’s social behavior change: Effects of developmentally integrated and segregated settings. Analysis and Intervention in Developmental Disabilities, 3, 23-34.
Systematic reviews of scientific studies:
•        McConnell, S. (2002). Interventions to facilitate social interaction for young children with autism: Review of available research and recommendations for educational intervention and future research. Journal of Autism and Developmental Disorders, 32, 351-372.
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3#
发表于 2008-11-25 16:47:51 | 只看该作者

re:谢谢楼主分享的信息。嗯,正是因为我在...

谢谢楼主分享的信息。
嗯,正是因为我在这行中,所以反而不关注那些Cause,marker,Pharm啥的,因为我知道那些都指望不上。

只是遗憾于:

下面引用由[U]睿妈妈[/U]发表的内容:
......
Note that I did not review behavioral approaches to treatment because your child is already participating in one but can do so if you wish.

.....


他问你wish不wish,我倒wish你能一连串回他:“Yes!  Of course!  Why not!  Certainly!”
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 楼主| 发表于 2008-11-25 14:35:11 | 只看该作者

re:Biomarkers...

Biomarkers
            J Autism Dev Disord. 2008 Oct 13. [Epub ahead of print]   Links
Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism.
Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE.
Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT, 06520, USA, flora.vaccarino@yale.edu.
Increased brain size is common in children with autism spectrum disorders. Here we propose that an increased number of cortical excitatory neurons may underlie the increased brain volume, minicolumn pathology and excessive network excitability, leading to sensory hyper-reactivity and seizures, which are often found in autism. We suggest that Fibroblast Growth Factors (FGF), a family of genes that regulate cortical size and connectivity, may be responsible for these developmental alterations. Studies in animal models suggest that mutations in FGF genes lead to altered cortical volume, excitatory cortical neuron number, minicolum pathology, hyperactivity and social deficits. Thus, many risk factors may converge upon FGF-regulated pathogenetic pathways, which alter excitatory/inhibitory balance and cortical modular architecture, and predispose to autism spectrum disorders.
PMID: 18850329 [PubMed - as supplied by publisher
             Am J Occup Ther. 2008 Sep-Oct;62(5):554-63. Links
Out-of-school participation patterns in children with high-functioning autism spectrum disorders.
Hilton CL, Crouch MC, Israel H.
Social Development Studies, Department of Psychiatry, Washington University School of Medicine, 18 S. Kingshighway Blvd., Ste. L-100, St. Louis, MO 63108, USA. hiltonc@psychiatry.wustl.edu
PURPOSE: This study examined differences in out-of-school activity participation between typically developing children and those with high-functioning autism spectrum disorders (HFASD). METHOD: Children with HFASD, ages 6 to 12 (N = 52), and a control group (N = 53) were assessed using the Children's Assessment of Participation and Enjoyment and the Social Responsiveness Scale. RESULTS: Significant differences were seen in participation between typical and HFASD groups in number of activities in which children participate, the numbers of individuals with whom they participate, and the variety of environments in which they participate. CONCLUSIONS: These findings indicate that out-of-school participation is significantly different for children with HFASD than for typically developing peers. Findings suggest that social impairment is related to some aspects of participation and that addressing social skills in intervention could contribute to increased participation in out-of-school activities by children with HFASD, which would contribute to their long-term mental and physical health.
PMID: 18826016 [PubMed - in proce

             Pediatr Clin North Am. 2008 Oct;55(5):1129-1146.   Links
Autism: Definition, Neurobiology, Screening, Diagnosis.
Rapin I, Tuchman RF.
Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA; Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY, USA.
Autism (ie, the autism spectrum disorders) is now recognized in 1 in 150 children. This article highlights the definition, neurobiology, screening, and diagnosis of autism. The genetics, immunology, imaging, and neurophysiology of autism are reviewed, with particular emphasis on areas that impact pediatricians. Early recognition of the social deficits that characterize autism is key to maximizing the potential of these children.
PMID: 18929056 [PubMed - as supplied by publisher
.            Br J Psychiatry. 2008 Oct;193(4):338-9.   Links
Serum levels of P-selectin in men with high-functioning autism.
Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.
             J Autism Dev Disord. 2008 Sep 23. [Epub ahead of print]   Links
GABA(A) Receptor Downregulation in Brains of Subjects with Autism.
Fatemi SH, Reutiman TJ, Folsom TD, Thuras PD.
Department of Psychiatry, Division of Neuroscience Research, School of Medicine, University of Minnesota, 420 Delaware St SE, MMC 392, Minneapolis, MN, 55455, USA, fatem002@umn.edu.
Gamma-aminobutyric acid A (GABA(A)) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABA(A) receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann's Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABA(A) receptor subunit expression in the three brain areas. Our results demonstrate that GABA(A) receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism.
             Brain. 2008 Sep 26. [Epub ahead of print]   Links
Acquisition of internal models of motor tasks in children with autism.
Gidley Larson JC, Bastian AJ, Donchin O, Shadmehr R, Mostofsky SH.
Kennedy Krieger Institute, Baltimore, MD and Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, USA.
Children with autism exhibit a host of motor disorders including poor coordination, poor tool use and delayed learning of complex motor skills like riding a tricycle. Theory suggests that one of the crucial steps in motor learning is the ability to form internal models: to predict the sensory consequences of motor commands and learn from errors to improve performance on the next attempt. The cerebellum appears to be an important site for acquisition of internal models, and indeed the development of the cerebellum is abnormal in autism. Here, we examined autistic children on a range of tasks that required a change in the motor output in response to a change in the environment. We first considered a prism adaptation task in which the visual map of the environment was shifted. The children were asked to throw balls to visual targets with and without the prism goggles. We next considered a reaching task that required moving the handle of a novel tool (a robotic arm). The tool either imposed forces on the hand or displaced the cursor associated with the handle position. In all tasks, the children with autism adapted their motor output by forming a predictive internal model, as exhibited through after-effects. Surprisingly, the rates of acquisition and washout were indistinguishable from normally developing children. Therefore, the mechanisms of acquisition and adaptation of internal models in self-generated movements appeared normal in autism. Sparing of adaptation suggests that alternative mechanisms contribute to impaired motor skill development in autism. Furthermore, the findings may have therapeutic implications, highlighting a reliable mechanism by which children with autism can most effectively alter their behaviour.
PMID: 18819989 [PubMed - as supplied b
Treatment
             Pro Fono. 2008;20(3):165-70.   Links
Development of autistic children based on maternal responses to the Autism Behavior Checklist.
Tamanaha AC, Perissinoto J, Chiari BM.
Universidade Federal de S&atilde;o Paulo, S&atilde;o Paulo, Brasil. anacarina.otor@unifesp.epm.br
BACKGROUND: language and speech-language intervention. AIM: to evaluate the development process of autistic children, in a direct and indirect intervention context based on the responses of mothers to the Autism Behavior Checklist. METHOD: the research sample consisted of 11 mothers of children diagnosed, according to the criteria established by the DSM IVtr (APA, 2002), with autism (six) and with Asperger Syndrome (five) and who were seen at the Investigation Laboratory of Global Developmental Disorders of the Federal University of S&atilde;o Paulo. These children were randomly divided into two groups: Six were receiving both direct and indirect intervention (TG), and five were receiving indirect intervention exclusively (OG). The Autism Behavior Checklist (Krug et al., 1993) was used, adapted to the Portuguese language by Marteleto (2003). This behavior checklist (57 items) allows the detailed description of non-adaptable characteristics regarding the following areas: sensory, use of the body and object, Language, Psycho-social and Relational. The questionnaire was filled in during an interview on three occasions: at the beginning of intervention, after six months and at the end of 12 months. RESULTS: after statistical analysis it was observed that there was a greater development in the total scores and in the areas of language, psycho-social and relational for the TG. This suggests a greater development pattern during the studied period for this group. CONCLUSION: the mothers of both groups observed behavioral changes. The better scores observed for the TG is probably related to the effectiveness of direct intervention, and not to the lack of attention of parents in the OG in recognizing behavioral changes in their children.
PMID: 18852963 [PubMed - in process]
             Dev Psychopathol. 2008 Fall;20(4):1103-32.   Links
Neurodevelopment and executive function in autism.
O'Hearn K, Asato M, Ordaz S, Luna B.
University of Pittsburgh, PA 15213, USA. ohearnk@upmc.edu
Autism is a neurodevelopmental disorder characterized by social and communication deficits, and repetitive behavior. Studies investigating the integrity of brain systems in autism suggest a wide range of gray and white matter abnormalities that are present early in life and change with development. These abnormalities predominantly affect association areas and undermine functional integration. Executive function, which has a protracted development into adolescence and reflects the integration of complex widely distributed brain function, is also affected in autism. Evidence from studies probing response inhibition and working memory indicate impairments in these core components of executive function, as well as compensatory mechanisms that permit normative function in autism. Studies also demonstrate age-related improvements in executive function from childhood to adolescence in autism, indicating the presence of plasticity and suggesting a prolonged window for effective treatment. Despite developmental gains, mature executive functioning is limited in autism, reflecting abnormalities in wide-spread brain networks that may lead to impaired processing of complex information across all domains.
PMID: 18838033 [PubMed - in
            Am J Occup Ther. 2008 Sep-Oct;62(5):564-73. Links
Sensory processing and classroom emotional, behavioral, and educational outcomes in children with autism spectrum disorder.
Ashburner J, Ziviani J, Rodger S.
Autism Queensland, PO Box 354, Sunnybank, Queensland, Australia 4109. jilla@autismqld.com.au
OBJECTIVE: We explored the associations between sensory processing and classroom emotional, behavioral, and educational outcomes of children with autism spectrum disorder (ASD). METHOD: Twenty-eight children with ASD (with average-range IQ) were compared with 51 age- and gender-matched typically developing peers on sensory processing and educational outcomes. RESULTS: For children with ASD, the Short Sensory Profile scores Underresponsive/Seeks Sensation and Auditory Filtering explained 47% of the variance in academic performance, yet estimated intelligence was not a significant predictor of academic performance. Significant negative correlations were found between (1) auditory filtering and inattention to cognitive tasks, (2) tactile hypersensitivity and hyperactivity and inattention, and (3) movement sensitivity and oppositional behavior. CONCLUSION: A pattern of auditory filtering difficulties, sensory underresponsiveness, and sensory seeking was associated with academic underachievement in the children with ASD. Children who have difficulty processing verbal instructions in noisy environments and who often focus on sensory-seeking behaviors appear more likely to underachieve academically.
PMID: 18826017 [PubMed - in
            Am J Occup Ther. 2008 Sep-Oct;62(5):547-53. Links
You can know me now if you listen: sensory, motor, and communication issues in a nonverbal person with autism.
Shoener RF, Kinnealey M, Koenig KP.
TALK Institute and School, 395H Bishop Hollow Road, Newtown Square, PA 19073, USA. rach530@gmail.com
This case report describes an intensive approach to treating autism and provides an intersection between a first-person narrative paired with intervention and outcomes. In-depth conversations between a person with autism and an occupational therapist provide insight into understanding differences and difficulties in sensory processing and regulation, praxis, and communication. Individuals with autism may be intellectually and emotionally intact but hampered by deficits that interfere with the ability to move the body efficiently. These sensorimotor deficits underlie the ability to communicate with others and to develop relationships. This article illustrates the benefits of an intensive therapeutic program designed to address sensory and motor differences underlying communication, as well as the vital role the occupational therapist plays in addressing these underlying differences to improve functional communication and social participation.
PMID: 18826015 [PubMed - in
             Am J Occup Ther. 2008 Sep-Oct;62(5):538-46. Links
Outcomes of a pilot training program in a qigong massage intervention for young children with autism.
Silva LM, Ayres R, Schalock M.
Teaching Research Institute, Western Oregon University, PO Box 688, Salem, OR 97308, USA. lmtsilvaqigong@comcast.net
Sensory impairment is a common and significant feature of children on the autism spectrum. In 2005, a qigong massage intervention based on Chinese medicine and delivered by a doctor of Chinese medicine was shown to improve sensory impairment and adaptive behavior in a small controlled study of young children with autism. In 2006, the Qigong Sensory Training (QST) program was developed to train early intervention professionals to provide the QST intervention. This article describes the preliminary evaluation of the QST program as piloted with 15 professionals and 26 children and outcomes testing using standardized tests of sensory impairment and adaptive behavior. Results of outcomes comparing delivery by QST-trained therapists with delivery by a doctor of Chinese medicine showed that both groups improved and that there was no difference in outcome between the two groups. The intervention and training program are described, and implications for future research are discussed.
PMID: 18826014 [PubMed - in pro
           
            Child Adolesc Psychiatr Clin N Am. 2008 Oct;17(4):739-52, vii-viii.   Links
Pharmacotherapy of irritability in pervasive developmental disorders.
Stigler KA, McDougle CJ.
Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46202-5200, USA. kstigler@uipui.edu
Children and adolescents diagnosed with autism and related pervasive developmental disorders (PDDs) often sustain irritability, including aggression, self-injurious behavior, and tantrums. Research to date supports the use of the atypical antipsychotics as a first-line pharmacologic treatment for this target symptom domain in PDDs. Currently, the atypical antipsychotic risperidone is the only medication approved by the US Food and Drug Administration for irritability in youth with autism. Additional large-scale, placebo-controlled studies of other medications are needed to determine their efficacy for the treatment of irritability in this diagnostic group.
PMID: 18775367
            
            Child Adolesc Psychiatr Clin N Am. 2008 Oct;17(4):713-38, vii.   Links
Treatment of inattention, overactivity, and impulsiveness in autism spectrum disorders.
Aman MG, Farmer CA, Hollway J, Arnold LE.
Department of Psychology, Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA. aman.1@osu.edu
We reviewed the recent literature on medicines used to manage inattention, impulsiveness, and overactivity in children with pervasive developmental disorders (autistic disorder, pervasive developmental disorder not otherwise specified, Asperger's disorder) using computer searches of pharmacologic studies. A substantial number of reports were identified and summarized. The literature tends to be dominated by uncontrolled studies, although the number of controlled trials is growing. Findings are described for psychostimulants, noradrenergic reuptake inhibitors, antipsychotics, alpha adrenergic agonists, antidepressants, anxiolytics, cholinesterase inhibitors, N-methyl-D-aspartate receptor blockers, and antiepileptic mood stabilizers. Evidence for a positive effect is strongest for psychostimulants, noradrenergic reuptake inhibitors, antipsychotics, and alpha adrenergic agonists. Evidence for efficacy seems weakest for newer antidepressants, anxiolytics, and mood stabilizers.
PMID: 18775366
Parental stress

            J Commun Disord. 2008 Sep 4. [Epub ahead of print]   Links
Bossy and nice requests: Varying language register in speakers with autism spectrum disorder (ASD).
Volden J, Sorenson A.
Speech Pathology and Audiology, University of Alberta, Edmonton, AB T6G 2G4, Canada.
The ability to vary language style or register is important for successfully navigating social situations. For example, we speak differently to our boss than we do to our children. This project examined whether high-functioning speakers with ASD were able to vary the language used for requests along continua of "politeness/bossiness", whether any such adjustments were similar to those made by appropriately matched controls, and whether speakers with ASD were able to accurately interpret politeness/bossiness registers. High-functioning children and adolescents (aged 6-16) with ASD were compared to matched typically developing children and adolescents on ability to (1) produce both "nice" and "bossy" requests to puppet listeners and, (2) to judge which of two requests was more polite. Contrary to expectations, participants with ASD were as adept as controls in both producing and judging polite and bossy requests. These results suggest that, at least for high-functioning children and adolescents with ASD, some skill at adjusting language register exists in their repertoire. Future research should examine whether this skill is also present in younger children and in unstructured interactions. If these results hold, clinicians may be able to focus their intervention on teaching strategies for successful use of behaviours that already exist rather than training the responses themselves. Learning outcomes: The reader will become familiar with the functional importance of varying language registers or style according to situational demands. In addition, teaching a strategy for how to determine when a particular language behaviour should be used may sometimes be more effective than training the specific language response.
PMID: 18930471 [PubMed - as supplied by publisher
             Prax Kinderpsychol Kinderpsychiatr. 2008;57(7):521-35. Links
[Burden and need for assistance in parents of autistic children]
[Article in German]
Jungbauer J, Meye N.
Kath. Fachhochschule Nordrhein-Westfalen, Abteilung Aachen, Aachen. j.jungbauer@kfhnw.de
This article presents results from an in-depth interview study with parents of children suffering from autism, focusing burden, coping resources, and need for professional assistance. The results show that parents feel extremely burdened by the intensive care for their autistic child. Based on the results of this study, the article outlines a concept of assisting parents of autistic children. Components of the concept are e. g. counseling, initiation of self-help potential
J Pediatr Psychol. 2008 Sep 15. [Epub ahead of print]   Links
Parenting a Child with Autism: Contextual Factors Associated with Enhanced Daily Parental Mood.
Pottie CG, Cohen J, Ingram KM.
Department of Psychology, Virginia Commonwealth University, and Queen Elizabeth II Health Sciences Centre.
OBJECTIVE: To examine the extent to which social support, unsupportive interactions, support services, and disruptive child behaviors predict daily positive and negative mood in parents of children with autism. METHODS: Ninety-three parents of children with autism completed initial measures of disruptive child behaviors, and support services, then biweekly measures of daily stress, received emotional and instrumental social support, unsupportive social interactions, and mood over 3 months. RESULTS: Greater levels of daily positive mood were associated with more emotional and instrumental support, and less parenting stress and unsupportive interactions. Greater daily negative mood was associated with less emotional support and more parenting stress, unsupportive interactions, and disruptive child behaviors. Emotional support, unsupportive interactions, and disruptive child behaviors moderated the stress-mood relationship. CONCLUSIONS: Daily received social support and unsupportive interactions, and disruptive child behaviors are important predictors of daily mood. Identifying interpersonal processes that enhance psychological well-being may inform future parenting interventions.
PMID: 18794189 [Pu
           J Genet Psychol. 2008 Sep;169(3):245-59. Links
Sleep problems of parents of typically developing children and parents of children with autism.
Lopez-Wagner MC, Hoffman CD, Sweeney DP, Hodge D, Gilliam JE.
California State University, San Bernardino, Office of Institutional Research, San Bernardino, CA 92407, USA. mclopez@csusb.edu
Few researchers have investigated the relation of children's sleep problems to their parents' sleep problems. Children with autism have been reported to evidence greater sleep problems than do typically developing children (C. D. Hoffman, D. P. Sweeney, J. E. Gilliam, & M. C. Lopez-Wagner, 2006; P. G. William, L. L. Sears, & A. Allard, 2004). In the present study, parents (N = 106) of children independently diagnosed with autism (4-16 years of age; M= 8.20 years, SD = 2.69 years) reported greater sleep problems for themselves than did parents (N = 168) of typically developing children (4-15 years of age; M = 8.62 years, SD = 3.28 years). Children's sleep problems were related to parents' sleep problems for both groups; in the autism group, children's level of symptomatology was not related to their parents' sleep. The authors suggest areas for further research on the sleep problems of children and their parents, the potential interaction of these problems with children's symptomatic behavior, and the relations of these factors to child, parent, and family functioning.
PMID: 18788326
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