Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.
Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M.
Department of Human Development, University of Texas at Dallas, USA. jkern1@mednet.swmed.edu
N,N-dimethylglycine, a dietary supplement, has been reported to be beneficial in children with autism and pervasive developmental disorder. We examined the effectiveness of dimethylglycine in children with autism and pervasive developmental disorder in a double-blind, placebo-controlled study. Thirty-seven children between 3 and 11 years of age with a diagnosis of autism and/or pervasive developmental disorder were gender and age matched and randomly assigned to receive either placebo or dimethylglycine for 4 weeks. All children were assessed before and after treatment on two behavioral measures, the Vineland Maladaptive Behavior Domain and the Aberrant Behavior Checklist. Standardized neurologic examinations before and after treatment on 33 children showed no change. An overall improvement on all behavioral measures was observed for both the placebo and the dimethylglycine groups. However, the improvement among the children who received dimethylglycine was not statistically different from the improvement observed among the children who received the placebo. The children who participated in this study were a heterogeneous group, and their apparent responses to the dimethylglycine varied. Some children appeared to respond positively to the dimethylglycine, and there was a smaller proportion of negative changes in the dimethylglycine group, but the quantitative changes in the dimethylglycine behavioral assessments were not significantly different from what was observed among children who received placebo. 作者: mmm 时间: 2008-2-9 07:49 标题: re:只要十个孩子中的一个吃了有进步,所有的家... 只要十个孩子中的一个吃了有进步,所有的家长都会让孩子试试的。家长们才不会管那些统计学上的东西。
DMG本身不是什么神奇的东西,中文名为N,N-二甲基甘氨酸,是人体中新陈代谢出现的物质。关于DMG对于改善孤独症的效果,我努力查找文献报道,所得微乎其微。最被广泛引用的就是两个案例:一个是1965年苏联的一个对于改善儿童语言功能的报道,另一个就是韩国的一个针对孤独症的研究(39个3-7岁孩子,研究为1990年前,为期3个月)。这两个研究被Bernard Rimland(PhD,Director of Autism Research Institute)广泛引用,也正是这位老兄的推广,使得DMG变成‘治疗’孤独症最有名的化学物质(DMG在美国不被列入药物,也不是维生素, 而被列入Food)。但随后,亦有若干研究表明,DMG没有特定的疗效。