一则关于自闭症新药的消息

binfeng2000

先别鸡冻，还在老鼠身上折腾呢，是怎么回事还不知道，只是贴出来，表示有很多人在做不同方面的功。



KM-391 Showing Significant Improvements On Key Parameters In Animal Studies
BEVERLY, MA - March 29, 2010 - Cellceutix Corporation (OTCBB: CTIX), a bio-pharmaceutical company that develops small molecules to treat cancer and inflammatory disease, today announced positive results in an animal study of its recently acquired autism compound, KM-391.  In this carefully conducted study, KM-391 was given orally over 90 days to groups of rats at two dosage levels.  At each dosage level, KM-391 demonstrated significant improvements in the test animals when compared to both the “no treatment” group and the “active control” (fluoxetine) group on the parameters of brain plasticity, serotonin levels and behavioral function.  These parameters were selected as important indicators of the effect needed to successfully treat autism.

"We are extremely excited about the data on KM-391 and the potential for the compound in this area of urgent medical need," said George Evans, CEO of Cellceutix.  "Diagnoses of autism are rising dramatically and the disease takes a terrible toll on families.   There is a critical need for new treatments for autism and we are pleased to be part of the effort to find them."

"Research on autism has been difficult because there has been no reliable animal model," said Dr. Krishna Menon, Chief Scientific Officer of Cellceutix.  "Fortunately, we were able to tap into some cutting edge research to find a promising model for our study."

An audio link discussing this event is at: http://www.cellceutix.com/news/press-release-audio-3-29-2010.html

binfeng2000

press release

May 12, 2010, 9:28 a.m. EDT · :   

Recent Announcements Suggest Cellceutix Is Well Positioned With Autism Compound; Pfizer and Novartis Announcements Indicate Interest in Autism by Major Companies


BEVERLY, MA, May 12, 2010 (MARKETWIRE via COMTEX) -- Cellceutix Corporation /quotes/comstock/11k!ctix (CTIX 0.51, 0.00, 0.00%) , a developer of small compounds for the treatment of cancer, autism and inflammatory diseases, believes that recent announcements by major pharmaceutical companies support its strategy of developing a novel compound to treat autism spectrum disorder. The New York Times published an article on April 29th to report the results from a small, overseas study for the treatment of fragile X syndrome by the Switzerland-based pharmaceutical giant Novartis. Fragile X, a genetic disorder characterized by changes in part of the X chromosome, is believed by Novartis to be a key aspect in attacking developmental disorders such as autism and mental retardation. Pfizer has also recently announced an effort to develop treatments for autism spectrum disorder.

"These announcements indicate that Cellceutix is in a prime position in the development of treatments for autism spectrum disorder," said Leo Ehrlich, the Chief Financial Officer of Cellceutix. "We are developing a novel compound for a disorder which has few treatment options. In an area that people were once skeptical about pharmaceutical advancements being possible, it is encouraging to see other companies showing significant interest."

Cellceutix acquired the rights to KM-391, its compound for the treatment of autism spectrum disorder, last year and has been diligently developing the compound since. Cellceutix has already completed an animal study that shows very encouraging results. Details of the data from the study are available at the Cellceutix website at www.cellceutix.com.

About Cellceutix Cellceutix Corporation is a preclinical cancer and anti-inflammatory drug developer. Cellceutix owns the rights to eight drug compounds, including Kevetrin(TM), which it is developing as a treatment for certain cancers, and KM-391, which it is developing for the treatment of autism. More information is available on the Cellceutix web site at www.cellceutix.com.

This Press Release contains forward-looking statements that are based on our current expectations, beliefs and assumptions about the industry and markets in which Cellceutix Corporation operates. Such forward-looking statements involve known and unknown risks, uncertainties, and other factors that may cause Cellceutix's actual results to be materially different from any future results expressed or implied by these statements. Actual results may differ materially from what is expressed in these statements, and no assurance can be given that Cellceutix can successfully implement its core business strategy and improve future earnings.

The factors that may cause Cellceutix's actual results to differ from its forward-looking statements include: Cellceutix's current critical need for additional cash to sustain existing operations and meet ongoing existing obligations and capital requirements; Cellceutix's ability to implement its new product development and commercialization, enter into clinical trials, expand the intellectual property portfolio, and receive regulatory approvals in a timely and cost-effective manner. All forward-looking statements are also expressly qualified in their entirety by the cautionary statements included in Cellceutix's SEC filings, including its quarterly reports on Form 10-Q and its annual report on Form 10-K.

Kevetrin and KM-391 have not been studied in humans at this time. The Company's positive results in animal studies do not necessarily guarantee success in humans, though they may form the basis for beginning Phase 1 trials.

h02_0

看不懂英文

秋爸爸

我随手翻一下，意译，精确意思以原文为准。

Cellceutix公司的代号为KM-391一种小分子药物组分，在大鼠身上的做的高低两个剂量组的对照实验研究表明，它对自闭症有效果，效果评价来自“脑的可塑性、血清学、行为学观察”几个参数，正期待着和辉瑞或诺华大药厂合作，希望有钱进一步研究。

总得来说，报道更像是上市公司振奋股东用的公告。
这只是小动物的研究，就是离临床试验也都还早呢。他们自己清楚，自闭症的动物模型本就缺乏，包括那个大鼠模型都存在疑问，接下来的大动物试验他们自己都尚不知道该用啥来做。

寂寞沙洲

没鸡冻，麻木了，路过看看...

凡间的天使

希望在我有生之年出结果。

这是件多渺茫的事哟。