Lead chelation therapy -- a chemical treatment to remove lead from the body -- can significantly reduce learning and behavioral problems that result from lead exposure, a Cornell study of young rats finds.
However, in a further finding that has implications for the treatment of autistic children, the researchers say that when rats with no lead in their systems were treated with the lead-removing chemical, they showed declines in their learning and behavior that were similar to the rats that were exposed to lead.
Chelating drugs, which bind to lead and other metals in the blood, are increasingly being used for the treatment of autism in children.
"Although these drugs are widely used to treat lead-exposed children, there is remarkably little research on whether or not they improve cognitive outcomes, the major area of concern in relation to childhood lead poisoning," said Barbara Strupp, Cornell associate professor of nutritional sciences and of psychology and the senior author of the study, which was published in a recent issue of Environmental Health Perspectives.
Studies on the safety or effectiveness of the drugs for treating autism are similarly lacking, Strupp said.
Strupp added that to her knowledge this is the first report that shows that chelation therapy can reduce behavioral and learning problems due to lead exposure as well as the first to show that this type of treatment can have lasting adverse effects when administered in the absence of elevated levels of heavy metals.
The study used succimer (brand name, Chemet), the most widely prescribed drug for the treatment of lead poisoning. Doctors prefer succimer to other such drugs because it can be given orally on an outpatient basis, and it leaches less zinc, iron and other essential minerals out of the body. Although the Centers for Disease Control recommends chelation therapy only for children whose blood lead levels exceed 45 micrograms per deciliter, such drugs as succimer are commonly administered at much lower levels of exposure, due to concerns about lasting complications with even slightly elevated blood lead levels.
It is important to remove lead from the body as quickly as possible to prevent or lessen lasting damage to the developing brain. High-lead exposure from peeling lead-based paint can lead to coma, convulsions and even death. At lower levels, lead exposure causes attention deficits, delinquency and difficulty regulating emotions and can lower IQ scores at a rate of about one IQ point per microgram/deciliter of exposure.
The study used rats -- whose mental and behavioral responses to lead exposure are similar to humans' -- and exposed them to moderate- and high-lead levels (administered via mothers' milk). A third group -- the control -- was not exposed. Exposures were followed by a treatment with succimer or placebo. Immediately thereafter, the researchers conducted automated tests over six months on the rats' attention, memory and abilities to learn and regulate emotions.
The rats with moderate-lead exposure benefited greatly from the succimer: Their test results were indistinguishable from the control test results. Rats exposed to higher lead levels showed benefits in the emotional domain: After succimer treatment, they behaved similarly to the control group. However, the treatment only slightly improved their learning deficit.
In the group that had no lead exposure but were given succimer, "we found lasting cognition and emotion-regulation [deficits] that were as pervasive and large as rats with high lead exposure," said Strupp. She added that one possibility is that succimer, in the absence of lead, may disrupt the balance of such essential minerals as zinc and iron. "These findings raise concerns about the use of chelating agents in treating autistic children," she said.作者: 一生平安 时间: 2006-12-18 17:58 标题: re:请问 问号 我儿子正在排铅中,本来中毒不... 请问 问号 我儿子正在排铅中,本来中毒不很深,好象就是刚刚达到轻度的低值,安全值超一点.医生说这种情况应该排,加之儿子的一些累似中毒的行为问题,我就选择了排.用的是智桤颗粒用了半个多月吧.看了您的帖子,我有点醒悟了,因为他爸昨天就说这孩子近来怎么这么难管呢,老犟嘴,反正比以前难管,脾气更急,我们还以为是排铅的同时排走了一些微量元素,现在看来是副作用?请您给我点建议吧.谢谢了作者: thankstoyilin 时间: 2006-12-18 22:01 标题: re:目前医学认为，血铅含量略超安全值的情况下... 目前医学认为，血铅含量略超安全值的情况下，不需要药物排毒。在排除环境中可能的污染源（比如某些工厂）、给孩子养成良好卫生习惯、注意合理饮食等几个方面来改善。药物排毒是要非常谨慎的。